Crush the tablet in a container with water (volume not less than 100 ml) and wait for complete dissolution. You can also chew the tablet and drink plenty of water before eating. https://augmentin875mg.net Tablets are attributed to adults and children from 12 years old, with a weight of 40 kg or more. Depending on the course of the disease, the patient takes about 3 tablets per day after an equal number of hours. In some situations, it is allowed to take 4 tablets. The powder may be white or yellowish..
The solution should be administered very slowly – within 3-4 minutes.
Pharmacodynamics
Amoxicillin is a semi-synthetic broad-spectrum antibiotic that is active against many gram-positive and gram-negative microorganisms. Amoxicillin is destroyed by microbial enzymes beta-lactamases – and does not affect the microorganisms that produce these enzymes.
Clavulanic acid is an inhibitor of beta-l acts az, structurally related to penicillins, which has the ability to inactivate a wide range of beta-lactamases found in microorganisms resistant to penicillins and cephalosporins.
Clavulanic acid protects amoxicillin from the damaging effects of beta-lactamase and expands its spectrum of activity, including microorganisms that are usually resistant to amoxicillin. Clavulanic acid has sufficient efficacy against plasmid beta-lactamases, which most often determine the resistance of bacteria, and is not effective against chromosomal beta-lactamases type 1, which are not inhibited by clavulanic acid.
The presence of clavulanic acid in the drug protects amoxicillin from destruction by enzymes – beta-lactamases, which allows you to expand the antibacterial spectrum of amoxicillin.
The following is the in vitro combination activity of amoxicillin with clavulanic acid.
Bacteria commonly susceptible to a combination of amoxicillin with clavulanic acid.
Bacillis anthracis, Enterococcus faecalis, Listeria monocytogenes, Nocardia asteroids, Streptococcus pyogenes 1, 2, Streptococcus agalactiae 1, 2, Streptococcus spp. (other beta – hemolytic streptococci) 1,2, Staphylococcus aureus (sensitive to methicillin), Staphylococcus saprophyticus, coagulase-negative Staphylococcus spp. * (sensitive to methicillin).
Bordetella pertussis, Haemophilus influenzae 1, Helicobacter pylori, Moraxella catarrhalis 1 (Branhamella catarrhalis), Neisseria gonorrhoeae, Pasterurella multocida, Vibrio cholerae.
Clostridium spp., Peptococcus niger, Peptostreptococcus magnus, Peptostreptococcus micros, Peptostreptococcus spp.
Bacteroides spp. (including Bacteroides fragilis), Capnocytophaga spp., Eikenella corrodens, Fusobacterium nucleatum, Fusobacterium spp., Porphyromonas spp., Prevotella sp p.
Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.
Microorganisms for which acquired resistance to a combination of amoxicillin with clavulanic acid is likely
Escherichia coli 1, Klebsiella spp. (including Klebsiella oxytoca, Klebsiella pneumoniae 1), Proteus spp. (including Proteus mirabilis, Proteus vulgaris), Salmonella spp., Shigella spp.
Corynebacterium spp., Enterococcus faecium, Streptococcus pneumonia 1, 2, Streptococcus spp. groups of viridians.
Microorganisms that are naturally resistant to the combination of amoxicillin with clavulanic acid
Acinetobacter spp., Citrobacter jreundii, Enterobacter spp., Hajhia alvei, Legionella pneumophila, Morganella morganii, Providencia spp., Pseudomonas spp., Serratia spp., Stenotrophomonas maltophilia, Yersinia enterocolitica .
Chlamydia pneumoniae, Chlamydia psittaci, Chlamydia spp., Coxiella burnetti, Mycoplasma spp .
1 – for these microorganisms, the clinical efficacy of a combination of amoxicillin with clavulanic acid is shown.
2 – strains of these types of bacteria do not produce beta-lactamases. Sensitivity to amoxicillin suggests a similar sensitivity to the combination of amoxicillin with clavulanic acid.
Augmentin tablets dosage and method of use
For oral administration.
The dosage regimen is set individually depending on the age, body weight, kidney function of the patient, as well as the severity of the infection..
To reduce potential gastrointestinal disturbances and to optimize absorption, the drug should be taken at the beginning of a meal.
Treatment should not continue for more than 14 days without reviewing the clinical situation..
If necessary, it is possible to carry out step-by-step therapy (first, intravenous administration of the Augmentin® preparation in the dosage form; powder for the preparation of a solution for intravenous administration with the subsequent transition to the Augmentin® preparation in oral dosage forms).
Adults and children 12 years of age and older or weighing 40 kg or more
1 tablet 875 mg / 125 mg 2 times a day.
Special patient groups
Children under 12 years old with a body weight of less than 40 kg
Other dosage forms of Augmentin® are recommended..
Elderly patients
No dosage adjustment is required. In elderly patients with impaired renal function, the dose should be adjusted as described below for adults with impaired renal function..
Patients with impaired renal function
875 mg / 125 mg tablets should be used only in patients with creatinine clearance greater than 30 ml / min, with no dosage adjustment required.
In most cases, if possible, parenteral therapy should be preferred..
Patients with impaired liver function
Treatment is carried out with caution; regularly monitor liver function. There is not enough data to change the dosing regimen recommendations in such patients..
Composition and dosage forms
White tablets with the symbols “A”, “C” on both sides and a marked break in 2 halves in a foil package of 14 pieces with instructions in a cardboard box.
Each of them contains the main compounds:
- amoxicillin (trihydrate) – 875 mg;
- clavulanic acid (potassium salt) – 125 mg.